Pseudarthrosis - Find a specialist and information

Leading Medicine Guide Editors
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Leading Medicine Guide Editors

A bone fracture is painful and requires a lot of patience from the patient. Depending on which bone has been affected, healing can take several weeks or even months. However, if a bone has not healed properly even after more than six months and is still causing problems, pseudarthrosis may have developed .

Find out here what pseudoarthrosis is, what characteristics it has and which forms of therapy can be promising, as well as selected pseudoarthrosis specialists.

ICD codes for this diseases: M84.1, M96.0

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Brief overview:

  • What is pseudoarthrosis? If a bone fracture does not heal sufficiently after six months at the latest, it can lead to considerable discomfort, including pain and restricted movement.
  • Symptoms: pain, swelling, redness, restricted movement, hypermobility, unstable joints.
  • Diagnosis: Pseudoarthrosis is easy to recognize using X-rays, computer tomography and MRI.
  • Causes: Mechanical causes: mobilization too early, displacement of soft tissue or the fracture sites against each other, insufficient wound compression. Morbid causes: Infections, arterial diseases, diabetes mellitus.
  • Treatment: Depending on the cause, various therapies are possible, including bone stabilization, osteosynthesis, bone regeneration, removal of diseased tissue, nutritional supplements.
  • Specialist areas: Bone surgery and orthopaedics.

Article overview

What is pseudarthrosis?

With this type of complaint, you should not necessarily be guided by the name alone. It has nothing to do with normal osteoarthritis, which is usually caused by joint wear and tear.

The term "pseudarthrosis" is made up of "pseud" and "arthros". "Pseud" stands for false, "arthros" for joint. Pseudoarthrosis is therefore a false joint that occurs when fracture sites have not healed sufficiently after a bone fracture.

Although the bone ends grow together and form a joint, this does not become firm and stable, as it should be. As a result, a joint is formed between the fracture ends in the area of the former fracture site, which did not exist before. This false joint can lead to considerable problems such as pain and restricted movement. Pseudo and false joint are other terms under which pseudoarthrosis is known.

What is the difference between delayed fracture healing and pseudoarthrosis?

Normal undisturbed fracture healing takes around 4 to 6 weeks, but can also take longer, up to 12 weeks, in the case of complex fractures.

If a fracture has not healed after 12 weeks, this is referred to as delayed fracture healing, and after 6 months it is a case of pseudoarthrosis.

Long bones, also known as shaft bones, are particularly susceptible to pseudoarthrosis. These include the femur, scaphoid, ulna with radius and the humerus.

Unterarmfraktur mit Pseudarthrose - Roe ap
Pseudarthrosis in the forearm

What are the causes of pseudarthrosis?

Pseudarthrosis can have various causes. A basic distinction is made between mechanical and morbid causes of pseudarthrosis. Mechanical means that movement and pressure have led to a disruption in bone fracture healing. Morbid causes are pathological conditions outside the bone, most frequently metabolic disorders or pathogens.

What are "mechanical" causes?

Mechanical causes basically include everything that has to do with movement, most frequently premature loading and therefore insufficient immobilization. This is particularly important in the case of conservatively treated fractures. Conservative means that the ends of the bones are not fixed together by surgery using metal (wires, screws, plates), but that the aim is to allow the fracture to heal naturally. Surgical treatment is also known as osteosynthesis, "osteo" stands for bone and "synthesis" for union.

A prerequisite for conservative fracture treatment is that the bone ends are close together and in the correct position. Immobilization is usually carried out using a plaster cast (e.g. on the wrist) or physical rest (e.g. for rib fractures).

A fracture normally heals within 6 weeks. If the bone tissue has not yet healed, premature movement and weight-bearing can ultimately do more harm than good and, in the worst case, lead to pseudoarthrosis.

Other mechanical causes can be

  • the displacement of soft tissue into the fracture region, which can happen if there is bleeding or major bruising. The latter are usually due to
  • insufficient wound compression
  • displacement of the fracture sites in relation to each other if pressure or blows are applied from outside. This can also lead to corresponding complications in the event of a fall

What are "morbid" causes?

Morbid causes must also be taken into account, but are much rarer. This category includes

  • disturbed calcium metabolism
  • infections
  • smoking
  • Severe overweight or underweight
  • Narrowing of the arteries with resulting circulatory disorders
  • Diabetes mellitus

Morbid causes also include congenital metabolic disorders of the bone, although these are rarely the cause.

Are there different types of pseudarthrosis?

Pseudarthrosis can be divided into different categories based on the bone structure and the blood supply situation:

  • according to the structure of the bone into
    • hypertrophic pseudarthrosis, in which there is an increase in bone substance. However, the stability of this bone is reduced and it is therefore unable to fix the bone ends.
    • Atrophic pseudarthrosis, in which there is a reduction in bone and cartilage tissue. The problem of inadequate stability is obvious here.
  • after the blood supply to the bone tissue in the
    • vital pseudarthrosis, in which there is sufficient blood supply, and avital pseudarthrosis, in which there is insufficient blood supply.
    • avital pseudarthrosis with insufficient blood supply to the tissue.

There is often a combination of hypertrophic & vital on the one hand and atrophic & avital on the other. Atrophic avital pseudarthrosis has the worst chances of healing, but hypertrophic vital pseudarthrosis also often has a protracted and complex healing process and often has to be surgically revised to ensure correct healing in the correct axial position (i.e. without skewing).

How is pseudarthrosis recognized?

There are various signs that indicate pseudarthrosis. For example, a very slow-healing fracture can be the first sign. Persistent or even increasing pain - lasting longer than 4 to 6 months - is suspicious of pseudarthrosis. Typical symptoms can be

  • Pain in the area of the affected bones or joints
  • swelling
  • redness
  • Restricted movement
  • Hypermobility - the opposite of lack of mobility
  • Instability of the joints

If you experience these symptoms, you should definitely have a medical check-up and have the symptoms investigated. Imaging procedures, primarily an X-ray examination, can make the pseudarthrosis visible and enable a more precise diagnosis. The X-ray image shows a permanent bone gap at the site of the previous fracture that has not healed properly. Pseudarthrosis can be assessed even more precisely using computer tomography or magnetic resonance imaging .

How is pseudarthrosis treated?

The treatment depends on the type of pseudarthrosis. The treatment methods must be adapted to the respective cause. In the case of the vital form, a somewhat milder therapy can be used and the chances of recovery are very good. A consistent continuation of immobilization is often sufficient.

The situation is different with avital pseudarthrosis, which usually requires surgical intervention. With the help of so-called osteosynthetic measures (bone connections using metal plates or screws), good treatment success can often be achieved.

In most cases, the bone ends have to be "refreshed". This means that dead avital and infected bone tissue is removed. In some cases, however, this results in a defect in the bone structure, making it necessary to fill it by means of a bone donation. This can be done using a cell culture of the patient created specifically for this purpose or bone tissue is removed from another site. The iliac crest is a suitable donor site.

A ring fixator is a variant that is used to stabilize the bone. A ring fixator is a type of external holding system that can be easily removed again.

Also important: there is currently a lot of discussion about a blood test to predict susceptibility to pseudoarthrosis. If this is successful, appropriate measures can be taken directly at the time of the initial fracture. In addition, tissue samples from the section of bone affected by pseudoarthrosis can also be examined in a laboratory. This provides a better overview of the risk of pseudarthrosis and the chances of healing a fracture.

In summary, the following treatment measures are available for pseudarthrosis:

  • Bone-connecting, osteosynthetic methods (for example ring fixator)
  • Insertion of bone substance into the fracture gap
  • Removal of dead and infected tissue
  • Administration of certain nutritional supplements
  • Possibly soon possible: blood test to determine susceptibility to pseudoarthrosis.

Who treats pseudoarthrosis?

Several specialists may be involved in the treatment of pseudoarthrosis. For example, physicians from the field of bone surgery and specialists from the field of orthopaedics may be involved. The attending physician will refer the patient to the right expert.

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