Affective disorders: Specialists and information

Leading Medicine Guide Editors
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Leading Medicine Guide Editors

Affective disorders are mental disorders that are characterized by a pathological change in mood. This includes a mood in the direction of depressive-inhibited or in the direction of manic-elevated. Affective disorders include depression, mania and bipolar disorder (manic-depressive illness).

Below you will find further information and selected specialists for affective disorders.

ICD codes for this diseases: F30, F31, F32, F33, F34, F38, F39

Article overview

What are affective disorders?

Affective disorders are when a mood disorder is at the center of the problem. In other words, when the mood is either depressive-inhibited or manic-excited.

Affective disorders typically occur in phases: Before and after the depression or mania, the affected person exhibits moods in the normal range. In many cases, depressive and/or manic phases occur several times during a person's life. This is also referred to as recurring or "relapsing" disorders.

In addition to depression and mania, persistent affective disorders such as

  • dysthymia (permanently slightly depressed mood) and
  • cyclothymia (a mood that constantly alternates between mildly depressed and mildly elevated)

are also affective disorders.

Forms of affective disorders

Depression is divided according to its severity into mild, moderate and severe depressive episodes. In the case of severe depression, a distinction can also be made between depression with and without psychotic symptoms (loss of reference to reality).

Mania is divided into hypomanic (milder) and manic (more severe) episodes. In manic episodes, mania can occur with or without psychotic symptoms.

In addition to pure depressive or manic episodes, so-called mixed affective disorders can also occur. In these, a manic and a depressive state alternate in rapid succession. This is also referred to as bipolar disorder.

Manisch-depressiv oder bipolar
Affective disorders include depressive or manic phases or a combination of both © Axel Bueckert | AdobeStock

Course of affective disorders

Affective disorders can be unipolar or bipolar. In a unipolar course, only manic or depressive phases occur, whereby in the vast majority of cases only depression occurs, while repeated pure mania is very rare.

In a bipolar course, manic and depressive episodes alternate, although the alternation is not regular. Unipolar disorders are much more common than bipolar disorders.

Most affective disorders occur recurrently, i.e. in several phases. In only around 15 percent of all cases does depression only occur once.

How do affective disorders develop?

Affective disorders are caused by various influencing factors. These can include

  • a genetic predisposition,
  • stress in childhood,
  • physical illnesses,
  • current stress situations or conflicts as well as
  • hormonal or other biological changes.

are among them.

It is assumed that hereditary factors cause an increased predisposition to affective disorders.

However, other factors such as stressful situations or hormonal changes then trigger the phases of the illness.

  • The genetic predisposition is supported by findings that affective disorders occur more frequently in close family members. This clustering is also evident if, for example, children have not grown up in the family of the sufferer. However, the genes responsible are not exactly known.
  • Early experiences of loss and separation in childhood also occur more frequently in patients with depression.
  • Physical illnesses or the use of certain medications can trigger an affective disorder.
  • Current stress situations play a role in triggering affective episodes, as they occur more frequently in the run-up to depressive illnesses.
  • The influence of biological factors is supported, among other things, by the mode of action of antidepressants, as they interfere with the transmission of messenger substances (transmitters) in the brain.

Bipolar affective disorders

Around one to two percent of all people develop bipolar disorder in the course of their lives. Depressive episodes alternate with manic, hypomanic or mixed phases. On average, bipolar disorders begin earlier than pure depression: The average age of onset is 16 to 18 years. Women and men are affected equally often.

Bipolar disorders begin more frequently with mania than with depression. They are usually more severe than pure ("unipolar") depression, i.e. more episodes occur.

If the depressive episodes alternate with pronounced mania, this is also referred to as bipolar I disorder. If only mild hypomanic episodes occur alongside the depressive phases, the disorder is referred to as bipolar II.

As with pure depression, the episodes in bipolar disorders usually disappear completely. Nevertheless, 20 to 30 percent of those affected may be severely impaired by increased mood instability even during the illness-free phases.

The course of bipolar disorders is generally worse than that of unipolar depression. The rate of additional mental illnesses is higher, and the suicide rate is also higher at 15 to 30 percent.

Cyclothymia and dysthymia

Dysthymia refers to chronic (lasting at least two years) mild depressive disorders. They never reach the severity of full depression. However, additional depressive episodes often occur in the long term.

Around 6 to 10 percent of all people are affected. In the past, these forms were also referred to as neurotic depression.

Cyclothymia is characterized by alternating depressive and elevated moods over a period of at least two years without meeting the criteria for bipolar disorder. They occur in 0.5 to 1 percent of the population and progress to bipolar disorder in 15 to 30 percent of cases.

Mania

Mania is symptomatically the opposite of depression. The most important criteria for the diagnosis are

  • Heightened, infectious, sometimes irritable mood,
  • Increased drive,
  • flighty thinking (i.e. the patients go from "stick to stick"),
  • lack of feeling ill and lack of critical faculties,
  • extreme, barely interruptible flow of speech,
  • overestimation of their own abilities up to ideas of grandeur,
  • strong distractibility,
  • reduced need for sleep and increased libido.

The elevated mood of manic patients manifests itself in extremely high spirits, exuberance and cheerfulness. However, they are easily irritable. This means that it can easily turn into irritability with a clearly aggressive undertone. Self-esteem is heightened in mania, and self-reflection and, in particular, insight into the illness are correspondingly severely restricted.

The vegetative symptoms are also the antithesis of depression: patients

  • hardly need any sleep,
  • have an increased appetite,
  • feel particularly healthy and energetic and
  • often also have an increased libido.

Some manic patients therefore also engage in rapidly changing sexual contacts.

Manic patients are said to think in an unstable, fleeting and imaginative way. The content of their thoughts is constantly changing and outsiders are often unable to keep up. However, in contrast to schizophrenic symptoms, the connections between the trains of thought are still comprehensible, i.e. not disjointed.

Ideas of greatness with rapidly changing content often occur in manias: for example, patients think of themselves in rapid succession as a gifted singer and a highly sophisticated entrepreneur. These ideas can escalate into delusions of grandeur.

The increased drive manifests itself in increased activity and movement and a strong urge to speak. Many spontaneous thoughts and decisions can be implemented without criticism. This can lead to massive social problems if, for example, patients

  • plunge into financial ruin by implementing a spontaneous business idea,
  • behave in a completely uninhibited sexual manner or
  • do things for which they feel bitterly ashamed once the mania has healed.
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