Pulmonary emphysema is a chronic lung disease in which the alveoli are permanently damaged. Pulmonary emphysema causes the lungs to become overinflated, which limits gas exchange. This lung disease often occurs in conjunction with COPD and usually develops over the course of several years.
Typical symptoms include shortness of breath, coughing, and reduced physical endurance. Pulmonary emphysema is a chronic condition that can significantly impair quality of life. Smoking and exposure to pollutants are particularly common risk factors. Lung function declines continuously in emphysema as the lung tissue becomes damaged. Early diagnosis can help slow the progression of the disease.
What is pulmonary emphysema?
Pulmonary emphysema is a chronic obstructive pulmonary disease (COPD). It involves a permanent structural change in the lung tissue. This leads to a pathological enlargement or distension of the air-filled alveoli. For this reason, pulmonary emphysema is also known as “blistered lung,” “lung distension,” or “emphysema pulmonum.”
The walls of the alveoli break down, and new, larger cavities form. This reduces the surface area through which oxygen can pass into the blood. As a result, the oxygen content in the blood decreases, and more air remains in the lungs.
The lungs continue to expand, and their reduced elasticity makes breathing difficult. Affected individuals experience shortness of breath during physical exertion.
The diagnosis of pulmonary emphysema is based on an X-ray examination and a pulmonary function test.
Since pulmonary emphysema is incurable,
- avoiding harmful substances (e.g., smoking) and infections,
- patient education, and
- medication,
- and, if necessary, surgical treatment,
are of particular importance.
Causes of Pulmonary Emphysema
Smoking and persistent inflammation, such as severe viral bronchitis, are among the most significant causes of pulmonary emphysema.
Years of smoking can lead to the development of chronic bronchitis over time. This, in turn, can accelerate the distension of the lungs.
In addition,
- genetic factors, such as a congenital deficiency of the enzyme alpha-1-antitrypsin—which is important for lung elasticity—as well as
- the removal of sections of the lungs
are known causes. However, exposure to pollutants in the environment or in the workplace also contributes to the development of emphysema.
Symptoms of Emphysema
The symptoms develop only slowly and insidiously, so that the patient often does not notice them at first.
The reduced oxygen level and increased carbon dioxide level in the blood lead to
- shortness of breath during physical exertion,
- and in some cases, a bluish discoloration of the lips and nail beds.
As lung damage progresses, shortness of breath and difficulty breathing occur even at rest. Some patients also suffer from sleep disturbances accompanied by increased daytime fatigue and weight loss.
In cases of chronic bronchitis, coughing and sputum production are also present.

Diagnosis of Pulmonary Emphysema
The diagnostic process begins with a detailed medical history (a patient interview regarding symptoms and past medical history). This is followed by a physical examination.
This may already provide initial indications of pulmonary emphysema. While auscultating the lungs, doctors listen for typical breath sounds. An X-ray reveals diaphragmatic descent, in which the diaphragm is clearly displaced downward.
A suspected diagnosis of pulmonary emphysema is confirmed by pulmonary function testing. The severity of the disease can be determined by measuring the oxygen content in the blood (blood gas analysis).
Treatment of Pulmonary Emphysema
In pulmonary emphysema, the structures within the lungs are irreversibly destroyed. Even today, the disease is incurable.
The goal of pulmonary emphysema treatment is therefore to
- to halt or delay the progression of the disease and
- to alleviate the symptoms.
The patient must quit smoking, and exposure to other irritants must be eliminated.
Treatment for pulmonary emphysema is then tailored to the severity of the condition. It consists of both medication and non-medication-based therapies.
Drug therapy includes the administration of
- bronchodilators and anti-inflammatory drugs, as well as
- antibiotics and
- enzyme replacement therapy for alpha-1-antitrypsin deficiency
. In specialized training sessions, patients learn
- breathing techniques,
- coughing techniques,
- relaxation exercises, and
- how to take their medications correctly.
In some cases, long-term oxygen therapy or the insertion of airway valves can provide relief.
In cases of severe pulmonary emphysema, volume-reduction surgery is performed to remove diseased lung tissue. This relieves pressure on the remaining healthy lung tissue. In the end stage of the disease, a lung transplant may be considered.
Which specialists and specialized clinics treat pulmonary emphysema?
Specialists in pulmonary emphysema are pulmonologists. Additional tests (MRI, CT) are performed by specialists in radiology or nuclear medicine. Specialized pulmonary clinics are appropriate for the treatment of pulmonary emphysema.
Depending on the severity of the disease, however, thoracic surgeons or transplant specialists may also be consulted.
Conclusion
Pulmonary emphysema is a chronic lung disease in which the alveoli, in particular, suffer permanent damage. In the early stages, the condition often goes unnoticed, as pulmonary emphysema usually develops gradually. It is only in advanced stages that the typical overinflation of the lungs and a significant restriction of breathing become apparent. The most common cause is smoking, but genetic factors such as alpha-1 antitrypsin deficiency also play a role. In pulmonary emphysema, the alveoli are overdistended, which severely impairs the exchange of oxygen and carbon dioxide.
Emphysema is diagnosed through a physical examination, pulmonary function tests, and imaging procedures such as X-rays. These reveal that the overinflation of the lungs is worsening and that lung tissue is being increasingly destroyed. The condition often occurs alongside chronic bronchitis or chronic obstructive bronchitis. Processes such as tissue breakdown by proteases also contribute to the damage. Forms such as centrilobular emphysema, cicatricial emphysema, or the presence of bullae demonstrate the diversity of this lung disease.
If pulmonary emphysema is diagnosed, targeted diagnosis and treatment are crucial to slowing the progression of the disease. Medication and breathing exercises support the respiratory muscles and improve quality of life. It is particularly important to quit smoking completely to prevent further damage. In severe cases, such as advanced pulmonary emphysema, endoscopic or surgical procedures may also be used.
Life expectancy depends heavily on how early pulmonary emphysema is treated and how consistently the therapy is followed. Treatment measures aim to slow the progression of the disease and maintain the patient’s ability to tolerate physical exertion. Comorbidities such as bronchitis and pulmonary emphysema often further worsen the prognosis. Overall, early treatment is crucial for alleviating symptoms and preserving bronchiolar function for as long as possible.
FAQ
What is pulmonary emphysema?
Pulmonary emphysema is a chronic lung disease in which the alveoli are permanently damaged. This disrupts gas exchange and limits the supply of oxygen.
What are the symptoms of pulmonary emphysema?
Typical symptoms include shortness of breath, coughing, and reduced exercise tolerance. Breathing becomes particularly difficult during physical activity because the lungs are less efficient.
What causes pulmonary emphysema?
Pulmonary emphysema is often caused by smoking or exposure to pollutants. Alpha-1 antitrypsin deficiency can also be a cause of this lung disease.
How is pulmonary emphysema treated?
Treatment includes medication, breathing exercises, and, in advanced cases, surgical procedures such as lung volume reduction or lung transplantation. The goal is to alleviate symptoms and slow the progression of the disease.
Can pulmonary emphysema be prevented?
Quitting smoking is the most important step in reducing the risk. Avoiding air pollution and having regular lung function tests also help detect pulmonary emphysema early.
Share this article
Sources
- COPD-Deutschland e. V. (Selbsthilfe)
- lungenaerzte-im-netz.de
- S2k-Leitlinie zur Diagnostik und Therapie von Patienten mit chronisch obstruktiver Bronchitis und Lungenemphysem (COPD); AWMF-Registernr. 020/006
- flexikon.doccheck.com/de/Lungenemphysem
