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Lung Metastases – Thoracic Surgery, Radiation Therapy, and Surgical Treatment of Secondary Tumors and Lung Metastases

Sabine Schneider
Editor-in-Chief

Lung metastases are malignant lesions that form in the lungs as a result of a primary tumor. Metastases in the lungs often develop when tumor cells spread through the bloodstream or lymphatic system. Lung metastases are particularly common in colorectal cancer, breast cancer, and other types of cancer. Many patients with lung metastases do not initially notice any symptoms, as the metastases are often not detected until the disease has reached an advanced stage.

Typical symptoms may include coughing, shortness of breath, or chest pain. The diagnosis is usually made using computed tomography (CT) or other radiological imaging techniques. Treatment options for lung metastases include surgery, chemotherapy, and radiation therapy. The choice of treatment depends on the number and size of the metastases, as well as the patient’s overall health.

ICD codes for this disease: C78.0

Quick Overview:

Lung metastases are secondary tumors that originate from a so-called primary tumor located outside the lung. The metastases develop when cancer cells spread into the lung tissue. Depending on the type of primary tumor, lung metastases are treated with surgery or chemotherapy. Modern treatment options also include radiation therapy for lung metastases, radiofrequency ablation, and local ablative procedures.

Article Overview

Description & Symptoms of Lung Metastases

Lung metastases are not the same as lung cancer. They originate from another tumor and may therefore consist of tissue different from that of lung cancer. Lung metastases therefore require a different treatment.

Usually, lung metastases are present initially without causing any additional symptoms or discomfort. For this reason, they are often discovered by chance—for example, during an X-ray at a hospital.

Occasionally, however, the metastases may manifest as a persistent cough (with blood) or pneumonia.

Diagnosis of Lung Metastases

In most cases, doctors discover lung metastases only by chance, such as during a chest X-ray as part of a follow-up examination.

Computed tomography (CT) scans allow for much better and earlier detection of lung metastases.

Occasionally, in addition to these imaging tests, a tissue biopsy—e.g., via bronchoscopy—is necessary. This allows doctors to carefully plan treatment and, if necessary, consider surgery.

Lung metastases on an X-ray
Lung metastases are often found incidentally during a chest X-ray © therads | AdobeStock

Lung Metastases – Treatment and Therapy Options

The treatment of lung metastases can involve

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For many patients, chemotherapy or radiation therapy is necessary in addition to surgery.

Planning the treatment requires an interdisciplinary team of experts. This team usually consists of

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Surgical removal of the metastases at the hospital is the most effective way to treat them. Unfortunately, surgical removal of lung metastases is only possible in about one-third of patients.

Various tests are conducted prior to surgery. The location and number of metastases play a major role in determining whether and how surgery can be performed. Experts in thoracic surgery should be consulted to perform this procedure.

If it is not possible to treat the lung metastases surgically, chemotherapy is usually prescribed. This form of therapy is intended to halt the progression of the disease and improve the patient’s quality of life. Radiation therapy is generally used to shrink a tumor before surgery or to destroy any remaining tumor tissue afterward.

FAQ

What are lung metastases?

Lung metastases are secondary tumors that form in the lungs from a malignant primary tumor. These metastases develop when tumor cells spread through blood vessels or lymphatic channels. Lung metastases are not a separate tumor disease, but rather secondary tumors originating from another tumor outside the lungs.

What symptoms do lung metastases cause?

Many patients with lung metastases initially have no symptoms. Typical symptoms include coughing, shortness of breath, coughing up blood, or chest pain. Metastases in the lungs are often not detected until the disease has reached an advanced stage.

How are lung metastases diagnosed?

The diagnosis is usually made using CT (computed tomography) or other radiological imaging techniques. Biopsies, positron emission tomography (PET), or staging tests may also be necessary. A pulmonary function test also helps in planning a potential surgery.

What treatment options are available for lung metastases?

The treatment of lung metastases depends on the number and size of the metastases, their location, and the patient’s overall condition. Treatment options include surgery, chemotherapy, radiation therapy, radiation targeting the lung metastases, or minimally invasive procedures such as radiofrequency ablation. In thoracic surgery, lung metastases may be surgically removable.

When is surgery recommended for lung metastases?

Surgery is primarily considered when there are only a few lung metastases and no other metastases outside the lung. The goal of surgical removal is the complete resection of the metastasis while preserving lung function as much as possible. The decision is made through an interdisciplinary approach involving oncologists, radiologists, and thoracic surgeons.

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