Laryngeal cancer (laryngeal carcinoma): Find info & doctors

22.11.2023
Leading Medicine Guide Editors
Author
Leading Medicine Guide Editors

Laryngeal cancer is the name given to a malignant tumor located in the larynx. It is the most common cancer in the head and neck area and is also known as laryngeal carcinoma or laryngeal tumor. The malignant tissue growth mainly affects men over 65. Laryngeal cancer can sometimes cause loss of voice.

Further information on laryngeal cancer and doctors for the treatment of laryngeal cancer can be found below.

ICD codes for this diseases: C32

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Brief overview:

  • What is laryngeal cancer? A malignant tumor that forms in the larynx. It is classified according to its exact location - on the vocal cords, above or below the vocal folds.
  • Risk factors: Smoking is the main risk factor, but excessive alcohol consumption also promotes the formation of the tumor. Infection with HP viruses or contact with various chemical substances are also associated with this.
  • Symptoms: The main symptoms are a bloody cough, strong bad breath and weight loss. Other symptoms may include persistent hoarseness and scratchiness in the throat, difficulty swallowing and others.
  • Diagnosis: A laryngoscopy and microlaryngoscopy are performed first. Taking and examining a tissue sample, the use of imaging procedures (CT, MRI, X-ray) and, if necessary, other methods are also part of the standard diagnostics.
  • Treatment: The most important treatment option is surgical removal of the tumor. The exact procedure depends on the type of tumor. Radiotherapy or chemotherapy may be necessary afterwards.
  • Prognosis: The earlier the tumor is discovered, the better the chances of recovery. Younger people in good general health have a more favorable prognosis than older people with concomitant diseases.

Article overview

What is laryngeal cancer?

The larynx is located in the throat and connects the pharynx with the oesophagus and windpipe. It enables speech and breathing.

The malignant laryngeal tumor occurs in three forms:

  • Glottic laryngeal carcinoma: Affects the vocal cords (glottis) and is the most common type of laryngeal cancer.
  • Supraglottic laryngeal cancer: Grows above the vocal folds.
  • Subglottic laryngeal cancer: Grows below the vocal folds.

In advanced stages, laryngeal carcinoma forms metastases. They first appear in the neighboring lymph nodes and later in more distant regions of the body.

Statistically, 6 out of 10 people with laryngeal cancer are still alive 5 years after diagnosis (five-year prognosis).

Anatomie des Kehlkopfes
The location and anatomy of the larynx © bilderzwerg | AdobeStock

Causes and risk factors for laryngeal cancer

Smoking is considered the main risk factor for the development of this malignant tumor. Excessive consumption of alcohol also contributes to the development of laryngeal cancer. Smoking and alcohol have a direct influence on the formation of pathologically altered cells.

In addition, infection with human papilloma viruses (HPV) can promote the occurrence of laryngeal tumors.

Toxic chemical substances such as

  • chromium,
  • arsenic,
  • asbestos,
  • nickel and
  • polycyclic aromatic hydrocarbons (PAHs)

increase the risk of developing laryngeal cancer later in life. Some occupational groups come into contact with these toxic substances. Older houses may also contain asbestos cement panels, which increase the risk of cancer for residents.

Laryngeal cancer can also be genetic.

Symptoms of laryngeal cancer

The symptoms of laryngeal cancer depend on where the tumor forms on the larynx.

In the early stages of vocal cord cancer, those affected are often hoarse and have to clear their throat. This form of cancer can therefore be diagnosed at an early stage.

Other signs of laryngeal cancer are persistent scratchiness in the throat and a chronic cough. This is followed by clearly audible breathing noises and shortness of breath.

Supraglottic tumors can usually only be detected at a late stage. The patients

  • often have swollen cervical lymph nodes
  • suffer from difficulty swallowing
  • have a foreign body sensation ("lump") in the throat

Laryngeal tumors locatedbelow the glottis (glottis) manifest themselves in the form of

  • hoarseness,
  • coughing irritation and
  • later breathing difficulties

noticeable.

Hoarseness lasting longer than 3 weeks without any other recognizable cause (sore throat) may indicate laryngeal cancer. If you have these symptoms, please contact an ear, nose and throat specialist as soon as possible.

Advanced laryngeal cancer presents with less specific signs such as

  • bloody sputum
  • bad breath
  • weight loss

Diagnosis of laryngeal cancer

If a laryngeal tumor is suspected, the doctor will first perform a laryngoscopy. This is usually done with the help of a flexible endoscope and 90° angled optics. The patient is under general anesthesia. During the laryngoscopy, the doctor takes a tissue sample and sends it to the laboratory for examination. There it is examined for cancer cells.

Palpation of the throat or an ultrasound examination may also reveal swollen lymph nodes.

A microlaryngoscopy provides further information. For example, the doctor can see whether the tumor is growing inwards, outwards or under the mucous membrane and whether the vocal cords are still mobile.

Imaging technologies such as

  • Ultrasound,
  • computed tomography(CT) and
  • magnetic resonance imaging(MRI)

show the exact location and extent of the tumor.

The ENT specialist must also clarify whether there is another malignant tumor, for example in the oesophagus or lungs. To do this, he performs an esophagoscopy andbronchoscopy.

An X-ray of the lungs shows the size and location of the tumor.

Medical treatment of laryngeal cancer

The treatment of laryngeal cancer depends on

  • where the tumor is located,
  • how large it is and
  • what stage of cancer has been diagnosed.

The patient's state of health and age also play a role in the decision.

Based on these factors, the specialist will advise surgery and/or radiotherapy or chemotherapy. Sometimes the latter are also used together.

Surgery for early-stage laryngeal cancer

Early-stage laryngeal cancer has a favorable prognosis, as it can often be completely removed by surgery.

If it is located in an area that is easily accessible via the mouth, the tumor can be removed endoscopically and microscopically using a laser. This minimally invasive procedure leaves only a small incision and spares healthy tissue.

If this is not possible, the larynx is opened with a scalpel.

Patients usually have difficulty breathing after the operation. An artificial airway (tracheostoma) is usually placed temporarily at the front of the throat to ensure that the patient can breathe properly.

Surgery for advanced stages of laryngeal cancer

Laryngeal tumors in advanced stages are more difficult to operate on. They can only be treated by complete removal of the larynx(laryngectomy). If the cervical lymph nodes are already affected, they must also be removed.

After the surgical procedure, patients need a tracheostoma and speak through an artificial speaking valve.

Tumor cells may still be present in the body after the operation. In order to kill these, radiotherapy and/or medication (conservative treatment) is used in advanced tumor stages.

If the risk of surgery is too great for the patient, conservative therapy is the only treatment option. This is also the case at an earlier stage of the tumor.

In the 5 years following the operation, the patient should undergo regular check-ups.

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