Prof. - Tienush Rassaf - Angiology -

Prof. Tienush Rassaf

Specialist for Angiology, Department of General Cardiology, Sports cardiology in Essen

Prof. - Tienush Rassaf - Angiology -
Prof. Rassaf is very familiar with the extensive spectrum of cardiovascular medicine. The highly specialized physician has an outstanding expertise, especially in minimally invasive procedures involving cardiac catheters and in complex coronary artery diseases.

Special Clinical Focus

  • Angiology treatment
  • HOCM
  • CHD
  • LAA closure
  • MitraClip
  • Oncologic cardiology
  • PFO / ASD closure

About us Prof. Tienush Rassaf

The Department of Cardiology and Angiology at University Medicine in Essen provides the entire range of advanced cardiovascular medicine. Thanks to the proximity of the Department of Cardiology and Angiology, the Department of Cardiothoracic Surgery and the Department of Vascular Surgery, we guarantee the optimal care of our patients with short routes and ideally coordinated workflows. The hospital is divided into five different clinical areas, which are arranged for the treatment of out-patients and in-patients, as well as emergency cases. In close collaboration with the attending primary care physicians and private cardiologists, our team therefore guarantees complete one-stop care for our patients. Our range includes all areas of cardiovascular medicine including all therapeutic options for coronary heart disease, cardiac arrhythmias, cardiac valve conditions, cardiac insufficiency, aortic conditions, congenital cardiac defects, emergency and intensive care medicine.

Diagnostic Services

General and Acute cardiology

Our General and Acute Cardiology Section includes an Emergency Admissions Unit, the “Chest Pain Unit”, which has been established especially for the evaluation of emergency cardiology patients with suspect cardiac infarct and other cardiovascular emergencies.

The hospital has multiple stat-of-the-art Cardiac Catheter Laboratories, in which over 4,000 procedures are performed annually, together with examinations and treatments of the cardiovascular system.

A special preparation algorithm has been developed at our hospital for coronary interventions with increased risk. This comprises measures in the ward for the patient’s preparation (special clarification) and certain requirements in the cardiac catheter laboratory (cardiac support system, cardioanalgosedation).

We are one of the first hospitals in Germany to provide an Onco-cardiology Program. This provides guidance, diagnosis and concomitant therapy for cancer patients, prior to, during and following cardiotoxic treatment, for the prevention and treatment of cardiac conditions in the wake of cancer treatment. This innovative program also addresses the scientific analysis of the risk to those patients who have been given cancer treatment which may potentially affect cardiovascular functions. Close collaboration with the Department of Gynecology, Dermatology, Urology and the Western German Tumor Center and thanks to the application of the most advanced techniques, early damage to the heart can be recognized and treated early.

The area of activity of our hospital includes all diagnostic techniques in cardiovascular medicine, with a focus on cardiology. These are available both to out-patients in the Polyclinic and the clinics and to in-patients. One focus of functional diagnostics is echocardiography. Here, the beating heart is examined by means of ultrasound. Thanks to extensive examination protocols, a high degree of standardization and facilities with state-of-the-art equipment in our hospital, cardiac conditions can be recognized in the early stages.

Structural cardiac conditions

New techniques for minimal invasive, catheter-based treatment of cardiac valve conditions have been developed in the last decade, which have fundamentally changed the previous treatment concepts for patients with these conditions. Previously only surgically treatable structural heart conditions can now be treated using interventional techniques with very good results. Here, above all, the treatment of aortic valve stenosis and mitral valve stenosis by means of catheter techniques has been established. Together with cardiac vascular conditions (cardiac infarct, coronary heart disease), the focus here is also on congenital (atrial septal defect) and acquired cardiac defects (aortic valve stenosis, mitral valve stenosis) and vascular conditions, particularly of the aorta (aortic aneurysm, aortic dissection).

Rhythmology and Device Therapy

One focus of our Center for Electrophysiology and Rhythmology is the invasive and noninvasive diagnosis and treatment of cardiac arrhythmias.

Along with noninvasive examinations such as resting EKG, long-term EKG, ergometry, transthoracic and transesophageal echocardiography, our service portfolio includes interventional electrophysiology (including ablation therapy) and invasive and noninvasive device therapy (including CRT-D and S-ICD implantation). Cardiac insufficiency and intensive care In order to respond to the increasing number of patients with severe cardiac insufficiency, special structures have been created at the Department of Cardiology at the Western German Cardiac and Vascular Center in Essen to meet this need.

The central structure of our Center of Excellence for Cardiac Insufficiency is an in-patient ward tailored to the requirements of the patient with cardiac insufficiency, an artificial heart or a heart transplant – the “Heart Failure Unit (HFU)”. Here, patients with severe cardiac insufficiency, patients following a heart transplant and, in particular, patients following the implantation of an artificial heart can be comprehensively cared for and all therapeutic and diagnostic procedures can be performed.

Diagnostic and Interventional Angiology Here, the spectrum of the Department includes diagnosis, advice, medication / conservative treatment and, not least, minimal invasive, catheter-guided procedures (therapeutic interventions) for conditions of the arteries and veins. The most advanced and innovative techniques are drawn on for the identification and treatment of arterial, venous and lymphatic vascular conditions. A particular focus is placed on the diagnosis and treatment of atherosclerotic conditions such as extracranial and peripheral arterial occlusive disease (PAOD). In treating PAOD, we are able to rely on many years of expertise in the dilatation of constrictions and the reopening (balloon dilatation and recanalization) of longstanding arterial occlusions in the arteries of the upper leg and the lower leg and the pelvic arteries.

In our new Out-patient Cardiovascular Centre in Essen, , following clarification beforehand and in the case of a coronary diagnosis without intervention, the patient is able to undergo a cardiac catheter examination as an out-patient and to be discharged home again by as early as the afternoon. Transesophageal echocardiography including electric cardioversion can also be performed on an out-patient basis.

Therapeutic Services

  • Coronary heart disease including treatment of acute coronary syndrome including balloon dilatation (PTCA), rotablation and reopening of occluded coronary vessels (CTO), intravascular ultrasound (IVUS), optical coherence tomography (OCT) and fractional flow reserve measurement (FFR)
  • High risk procedures including cardiac support systems for interventional treatment of complex coronary heart disease
  • Acquired structural cardiac conditions including interventional treatment of aortic valve and mitral valve conditions
    • Interventional aortic valve replacement (TAVI)
    • Interventional mitral valve reconstruction (MitraClip© and PASCAL©) and tricuspid valve reconstruction
    • Valvuloplasty
  • Congenital cardiac defects including PFO, ASD and LAA closure
  • Interventional electrophysiology with complex ablation and device implantation (ICD, CRT, cardiac pacemaker, S-ICD)
  • Cardiac insufficiency including mechanical support systems and heart transplantation listing and follow-up care
  • Vascular conditions including the care of patients with acute aortic syndromes (aortic dissection, penetrating aortic ulcer, intramural hematoma)
  • Cardiac intensive care including the treatment of patients in acute cardiogenic shock
  • Diagnostic and interventional angiology treatment (recanalization, PTA, stent Implantation)
  • Cardiovascular emergency medicine - 24 h Chest-Pain Unit
  • Cardiovascular Imaging
  • Cardiovascular prevention and check-up examinations

Curriculum Vitae

Curriculum Vitae Prof. Tienush Rassaf

Scientific Training and Positions

since 01/2022 Certification of the Cardio-Oncology unit of the Department
of Cardiology and Vascular Medicine, University Hospital
Essen as ,ICOS Center of Excellence – Gold Status’ 
since 10/2021 Founding member and Vice President of the ICOS Chapter
since 04/2020 Vice Dean for Research, Medical Faculty, University
Duisburg Essen, Germany
since 04/2018 Founding member and chairmen of the working group
‘Cardiooncology’ of the German Cardiac Society (DGK)
since 01/2017 Director of the Department of Cardiology and Vascular
Medicine, West German Heart & Vascular Center Essen
(WHGZ), University Duisburg-Essen, Germany
since 2016 Medical Director of the West German Heart and Vascular
Center Essen (WHGZ), University Duisburg-Essen,
since 08/2015 Full Professor (W3) for Internal Medicine and Cardiology
and Director of the Department of Cardiology at the West
German Heart- and Vascular Center Essen (WHGZ),
University Duisburg-Essen, Germany
2013 – 2015 Vice-Director of the Department of Cardiology, Pulmonary
Diseases, and Vascular Medicine, Heinrich Heine
University Düsseldorf, Germany
2010 - 2015 Heisenbergprofessor (W2) for Internal Medicine and
Myocardial Infarction of the German Research Foundation
at the Heinrich Heine University Düsseldorf, Germany
2008 Habilitation and Venia Legendi in Internal Medicine
(Transport, Metabolism and Function of Nitric Oxide and
Nitrite in the Cardiovascular System)
2005 - 2008 Leader of the CardioBioTech Research group of the Dept.
of Cardiology, University Hospital Aachen, Germany
2002 - 2003 Postdoctoral fellow, Department of Cardiovascular
Physiology, Heinrich Heine University Düsseldorf, Germany
2001 – 2002 Postdoctoral fellow, Department of Molecular and Cellular
Physiology, Louisiana State University, Shreveport, LA,
2001 Doctoral thesis: The NO/O2 assay: Possibility of
simultaneous determination of nitric oxide and superoxide
anion radicals considering their interaction (‘Dr. med’ with
magna cum laude) at the Division of Cardiology, Pulmonary
Diseases and Vascular Medicine, Heinrich Heine University
Düsseldorf, Germany

Clinical Training and Positions

since 2016 Medical Director of the West German Heart and Vascular
Center Essen, University Duisburg-Essen, Germany 
since 08/2015 Director of the Department of Cardiology and Vascular
Medicine, University Hospital Essen, Germany
2013 – 2015 Vice-Director of the Department of Cardiology, Pulmonary
Diseases, and Vascular Medicine, Heinrich Heine University
Düsseldorf, Germany
2009 - 2015 Attending, Department of Cardiology, Pulmonary Diseases
and Vascular Medicine, University Hospital Düsseldorf,
Germany (Prof. Dr. M. Kelm)
2011 Board Certification ‘Angiology’
2011 Board Certification ‘Emergency Medicine’
2010 Board Certification ‘Cardiology’
2008 Board Certification ‘Internal Medicine’
2005 - 2009 Resident/Attending, Department of Cardiology, Pulmonary
Diseases, Vascular Medicine and Intensive Care Medicine,
RWTH Aachen, Germany
2003 - 2005 Resident, Department of Cardiology, Pulmonary Diseases
and Vascular Medicine, University Düsseldorf. Germany

Scholarships and Awards

2018 Fellow of the American College of Cardiology (FACC)
2010 Heisenberg professorship of the German Research
Foundation (DFG)
2009  Fellow of the European Society of Cardiology (FESC)
2009 Heisenberg scholarship of the German Research
2009 Ernest-Solvay-Research Award for Medicine and Pharmacy
2006 Hans and Gertie Fisher Research Award
2006 – 2007 Research scholarship of the Medical Faculty of the RWTH
Aachen, Germany
2002 – 2003 Research scholarship of the German Cardiac Society
2001 – 2002 Research scholarship of the German Research Foundation


since 2020 International Journal of Molecular Sciences (Section Editor) 
since 2019 Scientific Reports
since 2019 Cardio News (Chief Editor)
since 2016 European Journal of Medical Research (Section Editor)
since 2016 (Chief Editor, cardiology)
since 2013 Basic Research in Cardiology
since 2011 Journal of Molecular and Cellular Cardiology


Publications Prof. Tienush Rassaf

Selected Publications (last 6 years):
1. Totzeck M, Michel L, Lin Y, Herrmann J, Rassaf T. CAR-T cells, cardio-oncology, cardiotoxicity,
chimeric antigen receptor, cytokine release syndrome. Eur Heart J. 2022; in press.
2. Michel L, Helfrich I, Hendgen-Cotta UB, Mincu RI, Korste S, Mrotzek SM, Spomer A, Odersky A,
Rischpler C, Herrmann K, Umutlu L, Coman C, Ahrends R, Sickmann A, Löffek S, Livingstone E,
Ugurel S, Zimmer L, Gunzer M, Schadendorf D, Totzeck M, Rassaf T. Targeting early stages of
cardiotoxicity from anti-PD1 immune checkpoint inhibitor therapy. Eur Heart J. 2022; 43(4):316-329.
3. Michel L, Mincu RI, Mahabadi AA, Settelmeier S, Al-Rashid F, Rassaf T, Totzeck M. Troponins and
brain natriuretic peptides for the prediction of cardiotoxicity in cancer patients: a meta-analysis. Eur
J Heart Fail. 2020, 22(2):350-361.
4. Merz SF, Korste S, Bornemann L, Michel L, Stock P, Squire A, Soun C, Engel DR, Detzer J,
Lörchner H, Hermann DM, Kamler M, Klode J, Hendgen-Cotta UB, Rassaf T, Gunzer M, Totzeck
M. Contemporaneous 3D characterization of acute and chronic myocardial I/R injury and response.
Nat Commun. 2019, 10(1):2312.
5. Mahabadi AA, Rassaf T. Imaging of coronary inflammation for cardiovascular risk prediction. Lancet
2018, 392(10151):894-896.
6. Rammos C, Hendgen-Cotta UB, Totzeck M, Pohl J, Lüdike P, Flögel U, Deenen R, Köhrer K,
French BA, Gödecke A, Kelm M, Rassaf T. Impact of dietry nitrate on age-related diastolic
dysfunction. Eur J Heart Fail. 2016, 18(6):599-610.



University Hospital, Essen | Western German Cardiac and Vascular Center

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45122 Essen

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