Clin. Professor Dr. med. habil. Dr. med. Dr. Konstantinos Gousias

Publications

• Gousias K, Trakolis L, Simon M. Meningiomas with CNS invasion. Front Neuroscience, 2023
• Siebert HC, Eckert T, Bhunia A, Klatte N, Mohri M, Siebert S, Kozarova A, Hudson JW, Zhanf R, Zhang N, Li L, Gousias K, Kanakis D, Yan M, Jimenez-Barbero J, Kozar T, Nifantiev NE, Vollmer C, Brandenburger T, Kindgen-Milles D, Haak T, Petridis AK. Biomedicines, 2023, DOI:10.3390/biomedicines11051421
• Lamrechts MJ, Schroeder GD, Karamian BA, et al. AO Spine Upper Cervical Injury Classification International Members. Effect of surgical experience and spine subspecialty on the reliability of the AO Spine Upper Cervical Classification System. J Neurosurg Spine, 2022, DOI:10.3171/2022.6.SPINE22454
• Vaccaro AR, Lambrechts MJ, Karamian BA, et al. AO Spine Upper Cervical Injury Classification International Members. Global Validation of the AO Spine Upper Cervical Injury Classification. Spine (Phila Pa 1976), 2022, DOI:10.1097/BRS.0000000000004429
• Datsi A, Piotrowski L, Markou M, Koester K, Kohtz I, Lang K, Plöttner S, Käfferlein HU, Pleger B, Martinez R, Pintea B, Fried R, Müller M, Chapot R and Gousias K. Stroke-derived neutrophils demonstrate higher formation potential and impaired resolution of CD66b+ driven Neutrophil Extracellular Traps. BMC Neurol, 2022, DOI:10.1186/s12883-022-02707-0
• Agrawal R, Rompf C, Pranada AB, Vollmar P, De Lorenzo A, Hoyer A, Gousias K. Microbiological profile and infection potential of different cryopreserved skull flaps after decompressive hemicraniectomy. Is cryostorage at -80° better? BMC Res Notes, 2022, DOI: 10.1186/s13104-022-06042-y
• Gousias K, Theocharous T and Simon M. Mechanisms of cell cycle arrest and apoptosis in glioblastomas. Biomedicines, 2022, DOI:10.3390/biomedicines10030564
• Ring A, Beutel H, Bushart SU, Dellman NC and Gousias K. Keystone perforator flap in the reconstruction of extensive soft tissue defects after lumbosacral spondylodesis. Unfallchirurg, 2022, DOI:10.1007/s00113-021-01128-x
• Wetzel-Yalelis A, Karadag C, Lan L, Turowski B, Bostelmann R, Abusabha Y, Hofmann B, Gousias K, Agrawal R, Kaiser M, König M, Mijderwijk HJ and Petridis AK. The rupture of an anterior communicating artery does not associate with an asymmetry in the A1 or A2 arteries: a retrospective study of radiological features. Br J of Neurosurg, 2022, DOI:10.1080/02688697.2021.2016624
• NIHR Global Health Unit on Global Surgery. Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries. Lancet, 2022, DOI:10.1016/S0140-6736(22)01846-3
• NIHR Global Health Unit on Global Surgery. Elective surgery system strengthening: development , measurement, and validation of the surgical preparedness index across 1632 hospitals in 119 countries. Br J Surg, 2023, DOI:10.1093/bjs/znad092
• Gousias K, Pleger B, Markou M, Grözinger M, Sedaghat S, Pintea B, Schildhauer TA, Martinez R and Hamsen U. Distinct Behaviour of Traumatic versus Nontraumatic intracerebral Hematomas: Different Biology or Impact of Age? JNLS-A, 2021, DOI:10.1055/s-0041-1728764
• Eckert T, Cosel JV, Kamps B, Siebert HC, Zhang R, Zhang N, Gousias K, Petridis AK, Kanakis DN, Falahati K. Evidence for quantum chemical effects in receptor-ligand binding between integrin and collagen fragments — a computational investigation with an impact on tissue repair, neurooncology and glycobiology. Front in Molecul Biosciences, 2021, DOI:10.3389/fmolb.2021.756701
• CovidSurg Collaborative. Timing of surgery following SARS-Cov-2 infection: an international prospective cohort study. Anaesthesia, 2021, DOI:10.1111/anae.15458
• CovidSurg Collaborative. SARS-CoV-2 vaccination modelling for safe surgery to save live: data from an international prospective cohort study. Br J Surgery, 2021, DOI:10.1093/bjs/znab101
• CovidSurg Collaborative. Effect of preoperative isolation on postoperative pulmonary complications after elective surgery: an international prospective cohort study. Anaesthesia, 2021, DOI:10.1111/anae.15560
• CovidSurg Collaborative. SARS-CoV-2 infection and venous thromboembolism after surgery: an international prospective cohort study. Anaesthesia, 2021, DOI: 10.1111/anae.15563
• Pintea B, Boström A, Katsigiannis S, Gousias K, Rares P, Baumert B and Boström J. Prognostic Factors for Functional Outcome of Patients with Optic Nerve Sheath Meningiomas Treated with Stereotactic Radiotherapy-Evaluation of Own and Meta-Analysis of Published Data. Cancers, 2021, DOI:10.3390/cancers13030522
• Markou M, Pleger B, Grözinger M, Pintea B, Hamsen U, Koenen S, Schildhauer TA, Martinez R and Gousias K. Intake of NOAC is associated with hepatoma expansion of intracerebral hepatomas after traumatic brain injury. Eur J Traum Emerg Surg, 2019, DOI:10.1007/s00068-019-01228-9
• Rullmann M, Preusser S, Poppitz S, Heba S, Gousias K, Hoyer J, Schuetz T, Dietrich A, Mueller K, Hankir MK and Pleger B. Adiposity Related Brain Plasticity Induced by Bariatric Surgery. Front Human Neurosc, 2019, DOI: 10.3389/fnhum.2019.00290dfgdfgdf
• Hankir MK, Rullmann M, Seyfried F, Preusser S, Poppitz S, Heba S, Gousias K, Hoyer J, Schuetz T, Dietrich A, Mueller K and Pleger B. Roux-en-Y gastric bypass surgery progressively alters radiologic measures of hypothalamic inflammation in obese patients. J Clin Investig Insight, 2019, DOI: 10.1172/jci.insight.131329, (American Society for Clinical Investigation)
• Rapp C, Dettling S, Liu F, Ull AT, Warta R, Jungk C, Roesch S, Mock A, Sahm F, Schmidt M, Jungwirth G, Zweckberger K, Lamszus K, Gousias K, Kessler AF, Grabe N, Loehr M, Ketter R, Urbschat S, Senft C, Westphal M, Abdollahi A, Debus J, von Deimling A, Unterberg A, Simon M and Herold-Mende CC. Cytotoxic T-cells and their activation status are independent prognostic markers in meningiomas. Clin Cancer Res, 2019, DOI: 10.1158/1078-0432.CCR-19-0389, (American Association for Cancer Research)
• Martinez-Olivera R, Datsi A, Stallkamp M, Koeller M, Kohtz I, Pintea B and Gousias K. Silencing of the nucleocytoplasmic shuttling protein karyopherin a2 promotes cell-cycle arrest and apoptosis in glioblastoma multiforme. Oncotarget, 2018, DOI: 10.18632/oncotarget.26033
• Gousias K and Simon M. Function outcome related to aggressive surgery for meningioma? Response. J Neurosurgery. 2018, DOI:10.3171/2017.10.JNS172487, (American Association of Neurological Surgeons)
• Pintea B, Baumert B, Kinfe TM, Gousias K, Parpaley Y and Bostroem JP. Early motor function after local treatment of brain metastases in the motor cortex region with stereotactic radiotherapy/radiosurgery or microsurgical resection: a retrospective study of two consecutive cohorts. Rad Oncol, 2017, DOI:10.1186/s12014-017-0917-6
• GliomaScan Consortium, Melin BS, Barnholtz-Sloan JS, Wrensch MR, Johansen C, Il'yasova D, Kinnersley B, Ostrom QT, Labreche K, Chen Y, Armstrong G, Liu Y, Eckel-Passow JE, Decker PA, Labussière M, Idbaih A, Hoang-Xuan K, Di Stefano AL, Mokhtari K, Delattre JY, Broderick P, Galan P, Gousias K, Schramm J, Schoemaker MJ, Fleming SJ, Herms S, Heilmann S, Noethen MM, Wichmann HE, Schreiber S, Swerdlow A, Lathrop M, Simon M, Sanson M, Andersson U, Rajaraman P, Chanock S, Linet M, Wang Z, Yeager M;, Wiencke JK, Hansen H, McCoy L, Rice T, Kosel ML, Sicotte H, Amos CI, Bernstein JL, Davis F, Lachance D, Lau C, Merrell RT, Shildkraut J, Ali-Osman F, Sadetzki S, Scheurer M, Shete S, Lai RK, Claus EB, Olson SH, Jenkins RB, Houlston RS and Bondy ML. Genome-wide association study of glioma subtypes identifies specific differences in genetic susceptibility to glioblastoma and non-glioblastoma tumors. Nature Genetics, 2017, DOI:10.1038/ng.3823
• Schmidt M, Mock A, Jungk C, Sahm F, Ull AT, Warta R, Lamszus K, Gousias K, Ketter R, Roesch S, Rapp C, Schefzyk S, Urbschat S, Lahrmann B, Kessler AF, Loehr M, Senft C, Grabe N, Reuss D, Beckhove P, Westphal M, Deimling AV, Unterberg A, Simon M and Herold-Mende C. Transcriptomic analysis of aggressive meningiomas identifies PTTG1 and LEPR as prognostic biomarkers independent of WHO grade. Oncotarget, 2016, DOI: 10.18632/oncotarget.7396
• Gousias K, Schramm J and Simon M. The Simpson grading revisited: aggressive surgery still has a place in modern meningioma management. J Neurosurgery, 2016, DOI:10.3171/2015.9.JNS15754, (American Association of Neurological Surgeons)
• Sahm F, Schrimpf D, Koelsche C, Reuss D, Bissel J, Kratz A, Capper D, Adeberg S, Brehmer S, Schittenhelm J, Becker A, Brokinkel B, Schmidt M, Ull T, Gousias K, Kessler AF, Lamszus K, Debus J, Mawrin C, Kim YJ, Simon M, Ketter R, Paulus W, Herold-Mende C and von Deimling A. TERT promoter mutations occur in malignant meningioma and identify patients at risk for early recurrence. J Nat Cancer Inst, 2015, DOI: 10.1093/jnci/djv377
• Kinnersley B, Mitchell J, Gousias K, Schramm J, Idbaih A, Labussière M, Marie Y, Rahimian A, Wichmann HE, Schreiber S, Hoang-Xuan K, Delattre JY, Noethen M, Mokhtari K, Lathrop M, Bondy M, Simon M, Sanson M and Houlston M. Quantifying the heritability of glioma using genome-wide complex trait analysis. Scie Rep, 2015, DOI: 10.1038/srep17267
• Kinnersley B, Labussière M, Holroyd A, Di Stefano AL, Broderick P, Vijayakrishnan J, Mokhtari K, Delattre JY, Gousias K, Schramm J, Schoemaker MJ, Fleming SJ, Herms S, Heilmann S, Schreiber S, Wichmann HE, Noethen MM, Swerdlow A, Lathrop M, Simon M, Bondy M, Sanson M and Houlston RS. Genome-wide association study identifies multiple susceptibility loci for glioma. Nature Commun, 2015, DOI: 10.1038/ncomms9559
• Kinnersley B, Kamatani Y, Labussière M, Wang Y, Galan P, Mokhtari K, Delattre JY, Gousias K, Schramm J, Schoemaker MJ, Swerdlow A, Fleming SJ, Herms S, Heilmann S, Noethen MM, Simon M, Sanson M, Lathrop M and Houlston RS. Search for new loci and low-frequency variants influencing glioma risk by exome-array analysis. Europ J Human Genetics, 2015, DOI: 10.1038/ejhg.2015.170
• Simon M, Hosen I, Gousias K, Rachakonda S, Herdenreich B, Gessi M, Schramm J, Hemminki K, Waha A and Kumar R. TERT promoter mutations: a novel independent prognostic factor in primary glioblastomas. Neurooncology, 2015, DOI:10.1093/neuonc/nou158
• Gousias K, von Ruecker A, Gielen GH, Niehusmann P, Wada A, Vatter H. and Simon M. A potential role of karyopherin a2 in the impaired maturation of dendritic cells observed in glioblastoma patients, Neuroimmunol Neuroinflammation, 2015, DOI:10.4103/2347-8659.149396
• Gousias K, Voulgaris S, Vartholomatos G, Voulgari P, Kyritsis AP and Markou M. Prognostic value of the preoperative immunological profile in patients with globlastomas. Surg Neurology Internat, 2014, DOI:10.4103/2152-7806.134104.eCollection 2014
• Gousias K, Niehusmann P, Gielen GH and Simon M. Karyopherin a2 and chromosome region maintenance protein 1 expression in meningiomas: novel biomarkers for recurrence and malignant progression. J Neurooncol , 2014, DOI:10.1007/s11060-014-1423-4
• Gousias K, Niehusmann P, Gielen GH, Simon M. and Bostroem J. KPNA2 predicts long term survival in patients with anaplastic oligoastrocytomas. J Clin Neurosc, 2014, DOI:10.1016/j.jocn.2014.01.011
• Gousias K, Schramm J. and Simon M. Extent of resection and survival in supratentorial infiltrative low-grade gliomas: analysis of and adjustment for treatment bias. Acta Neurochirurg (Wien), 2014, DOI:10.1007/s00701-013-1945-0
• Gousias K, von Ruecker A, Voulgari P. and Simon M. Phenotypical analysis, relation to malignancy and prognostic relevance of ICOS+T regulatory and dendritic cells in patients with gliomas. J Neuroimmunol 2013, DOI:10.1016/j.jneuroim.2013.09.001
• Enciso-Mora V, Hosking FJ, Di Stefano AL, Zelenika D, Shete S, Broderick P, Idbaih A, Delattre JY, Hoang-Xuan K, Marie Y, Labussière M, Alentorn A, Ciccarino P, Rossetto M, Armstrong G, Liu Y, Gousias K, Schramm J, Lau C, Hepworth SJ, Schoemaker M, Strauch K, Mueller-Nurasyid M, Schreiber S, Franke A, Moebus S, Eisele L, Swerdlow A, Simon M, Bondy M, Lathrop M, Sanson M and Houlston RS, Low penetrance susceptibility to glioma is caused by the TP53 variant rs78378222. Br J Cancer, 2013, DOI:10.1038/bjc.2013.155
• Enciso-Mora V, Hosking FJ, Kinnersley B, Wang Y, Shete S, Zelenika D, Broderick P, Idbaih A, Delattre JY, Hoang-Xuan K, Marie Y, Di Stefano AL, Labussière M, Dobbins S, Boisselier B, Ciccarino P, Rossetto M, Armstrong G, Liu Y, Gousias K, Schramm J, Lau C, Hepworth SJ, Strauch K, Mueller-Nurasyid M, Schreiber S, Franke A, Moebus S, Eisele L, Forsti A, Hemminki K, Tomlinson IP, Swerdlow A, Lathrop M, Simon M, Bondy M, Sanson M. and Houlston RS. Deciphering the 8q24.21 association for glioma. Hum Molec Genet, 2013, DOI:10.1093/hmg/ddt063
• Wang X., Boisselier B, Rossetto M, Marie Y, Idbaih A, Mokhtari K, Gousias K, Hoang-Xuan K, Delattre JY, Simon M, Labussière M and Sanson M. Prognostic impact of the isocitrate dehydrogenase 1 single-nucleotide polymorphism rs11554137 in malignant gliomas. Cancer, 2013, DOI:10.1002/cncr.27798
• Jacobs DI, Walsh KM, Wrensch M, Wiencke J, Jenkins R, Houlston RS, Bondy M, Simon M, Sanson M, Gousias K, Schramm J, Labussière M, Di Stefano AL, Wichmann HE, Mueller-Nurasyid M, Schreiber S, Franke A, Moebus S, Eisele L, Dewan AT, and Dubrow R. Leveraging ethnic group incidence variation to investigate genetic susceptibility to glioma: a novel candidate SNP approach. Front Genetics, 2012, DOI:10.3389/fgene.2012.00203
• Gousias K, Becker AJ, Simon M. and Niehusmann P. Nuclear karyopherin a2: a novel biomarker for infiltrative astrocytomas. J Neurooncol, 2012, DOI:10.1007/s11060-012-0924-2
• Sanson M, Hosking FJ, Shete S, Zelenika D, Dobbins SE, Ma Y, Enciso-Mora V, Idbaih A, Delattre JY, Hoang-Xuan K, Marie Y, Boisselier B, Carpentier C, Wang XW, Di Stefano AL, Labussière M, Gousias K, Schramm J, Boland A, Lechner D, Gut I, Armstrong G, Liu Y, Yu R, Lau C, Di Bernardo MC, Robertson LB, Muir K, Hepworth S, Swerdlow A, Schoemaker MJ, Wichmann HE, Mueller M, Schreiber S, Franke A, Moebus S, Eisele L, Foersti A, Hemminki K, Lathrop M, Bondy M, Houlston RS and Simon M. Chromosome 7p11.2 (EGFR) variation influences glioma risk. Hum Molec Gen, 2011, DOI:10.1093/hmg/ddr192
• Gousias K and Kyritsis A. Comment on "Opportunistic cytomegalovirus infection in a patient receiving temozolomide for treatment of malignant glioma". J Clin Neurosc. 2010, Vol.17, No.3, pp.412, DOI:10.1016/j.jocn.2009.07.097
• Simon M, Hosking FJ, Marie Y, Gousias K, Boisselier B, Carpentier C, Schramm J, Mokhtari K, Hoang-Xuan K, Idbaih A, Delattre JY, Lathrop M, Robertson LB, Houlston RS and Sanson M. Genetic risk profiles identify different molecular etiologies for glioma. Clin Cancer Res, 2010, DOI:10.1158/1078-0432.CCR-10-1502, (American Association for Cancer Research)
• Gousias K, Bostroem J, Kovacs A, Niehusmann P, Wagner I, Kristof R. Factors of influence upon overall survival in the treatment of intracranial MPNSTs. Review of the literature and report of a case. Rad Oncol, 2010, DOI:10.1186/1748-717x-5-114
• Gousias K, Markou M, Arzoglou V, Voulgaris S, Vartholomatos G, Kostoula A, Voulgari P, Polyzoidis K and Kyritsis AP. Frequent abnormalities of the immune system in gliomas and correlation with the WHO grading system of malignancy. J Neuroimmunol, 2010, DOI:10.1016/j.jneuroim.2010.05.027
• Gousias K, Markou M, Voulgaris S, Goussia A, Voulgari P, Bai M, Polyzoidis K, Kyritsis A and Alamanos Y. Descriptive epidemiology of cerebral gliomas in northwest Greece and study of potential predisposing factors, 2005-2007. Neuroepidemiol, 2009, DOI:10.1159/000222090
• Voulgaris S, Partheni M, Gousias K, Polyzoidis K and Konstantinou D. Solitary plasmacytoma of the upper cervical spine: therapeutic considerations. J Neurosurg Scie, 2008, Vol.52, No.2, pp.55-59,
• Tzortzidis F, Partheni M, Voulgaris S, Gousias K and Konstantinou D. Resection of giant meningiomas of the anterior cranial fossa using orbital osteotomies. J Neurosurg Scie, 2005, Vol.49, No.3, pp. 77-84

• Gousias K and Simon M. Aggressive surgery for invasive meningiomas, In. Mauri F, Meningiomas from Pathology to Clinics, Springer, in preparation
• Gousias K, Tzaridis T, Broekman M. Advancing precision therapies for glioblastoma, e-book, Frontiers, in preparation
• Gousias K and Wilhelm W.Rückenmarkverletzung und Querschnittlähmung, In. Wilhelm W und Sakka S, Praxis für Intensivmedizin, Springer Verlag, 2023
• Gousias K and Simon M. Resektionsausmaß und Prognose bei Gliomen; ‘‘Viel hilft viel‘‘ oder ‘‘alles oder nichts‘‘?, In. Simon M, Gliomchirurgie, Springer Verlag, 2018
• Gousias K, Molecular and cellular biology of patients with gliomas. Correlation with WHO grade of malignancy and prognostic relevance. Rheinische Friedrich-Wilhelms-Universität Bonn Verlag, 2014
• Gousias K. Karyopherin a2: ein neuer Biomarker für infiltrative Astrozytome, Rheinische Friedrich-Wilhelms-Universität Bonn Verlag, 2012
• Gousias K. Epidemiological and immunological study in patients with cerebral gliomas. In: Gousias K. Publisher: University of Ioannina 2010

• Pintea, B., Simon. M, and Gousias, K. (2018), “Different considerations upon tumor recurrence after surgery for meningiomas WHO grade II ” Proceeding of Annual Meeting of EANS, Brussels, Belgium, October 21-25, 2018. BEST ABSTRACT FOR SKULL BASE SURGERY
• Gousias, K., Schramm, J. and Simon, M (2010) “Extent of resection and survival in a series of 126 supratentorial infiltrative low grade gliomas. ” Proceedings of Annual Meeting of EANS, Groningen, Holland, March 25-27, 2010 TOP 20 ABSTRACTS OF THE MEETING

• Acromegaly
• Angioma
• Astrocytoma
• Brain injury
• Brain tumor
• Cauda equina syndrome
• Cavernoma
• Cerebral aneurysm
• Cerebral arteriovenous malformation
• Cerebral hemorrhage
• Cerebral metastases
• Cerebral vascular disorder
• Cervical spinal disk herniation
• Childhood nerve cancer
• Dystonia
• Flat Back Syndrome (post-op)
• Glioblastoma
• Glioma
• Hydrocephalus
• hyperprolactinemia
• hypopituitarism
• Intervertebral disc degeneration
• ISG syndrome
• Kyphosis
• Low Grade Glioma
• Lumbar spinal pain
• Meningeoma
• Meralgia paraesthetica
• Nerve cancer
• Neurofibromatosis
• Neurovascular disorders
• Oligodendroglioma
• Osteochondrosis
• Paralyses
• Pituitary adenoma
• Postnucleotomy syndrome
• Posttraumatic kyphosis
• Spinal canal disorders
• Spinal canal stenosis
• Spinal conditions
• Spinal cord injury
• Spinal cord tumor
• Spinal disk herniation
• Spinal fracture
• Spinal instability
• Spinal tumor
• Spondylitis
• Spondylodiscitis
• Spondylolisthesis
• Spondylopathy
• Spondylosis
• Subarachnoid hemorrhage
• Supinator syndrome
• Tethered cord syndrome
• Thoracic outlet syndrome
• Trigeminal neuralgia
• Tumor of the base of the skull
• Whiplash injury

• (Brachial) Plexus surgery
• Back pain treatment
• Brain pacemaker (neuropacemaker) / deep brain stimulation
• Brain surgery
• Cerebral aneurysm surgery
• Cerebral tumor surgery
• Facet infiltration
• Intervertebral disk surgery
• Intervertebral disk surgery to the cervical spinal column
• Kyphoplasty
• Minimal invasive (intervertebral) disk surgery
• Nerve reconstruction
• Neuromodulator
• Neuronavigation
• Neurosurgical pain treatment
• Percutaneous nucleotomy
• Percutaneous spinal surgery
• Spinal correction
• Spinal stabilization
• Spine stabilization surgery using cage
• Spondylodesis
• Stereotaxis
• Surgery to the base of the skull
• TLIF (transforaminal lumbar interbody fusion)

• Myelographie (myelogram)